You need to match the $priority you used to hook the action:
remove_action( 'save_post', array( $this, 'save_box' ), 20 /* Same as add_action call */ );
http://codex.wordpress.org/Function_Reference/remove_action
Make sure you take the $post_id argument in your save_box method too:
function save_box( $post_id ) {
...
}
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