WP e-Commerce is probably the best you are going to get while still keeping within the confines of WordPress. Keep in mind WordPress was designed originally for blogging, but it has expanded to do so much more.
For a really big store it is probably a good idea to go to dedicated store software like Magento or OS Commerce. If you want to start out with WP e-Commerce it should not be all that hard to move to another store with all your products once you outgrow WP e-Commerce.
Edit
I came across this question that may be of interest to you:
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