How to display fields from the loop in two separate divs

A simple solution would be just run the loop twice.

    <?php // set loop $args here so they're in once place ?>

    <div class="four">
        <?php // run the loop once with $args, output left side items ?>
    </div>
    <div class="five">
        <?php // run the loop again with $args, output right side items ?>
    </div>