Yes,
You can call action “pre_get_posts”.
add_action('pre_get_posts','search_filter');
You can add parameter :
$args = array(
'post_status' => 'publish',
'posts_per_page' => 6,
'paged' => $paged,
'meta_key' => 'event_date',
'orderby' => 'meta_value_num',
'order' => 'ASC'
);
You can use above parameter e.g. :
function search_filter($query){
if ( !is_admin() && $query->is_main_query() ) {
$query->set('post_status', 'publish');
$query->set('meta_key', 'event_date');
$query->set('orderby', 'meta_value_num');
$query->set('order', 'ASC');
}
}