I’ll just put the main pros/cons that quickly came to my mind here. This list is not extensive. For some more info on MS have a look at at the Codex.
Pro Multisite
- Maintain WordPress/Plugins/Themes just once. If you upgrade everything is upgraded at once
- Easily share content between sites. (e.g switch to blog)
- User Accounts can be cross-site
- Sites are totally independent
Contra Multisite
- You can’t update WordPress/Plugins/Themes separately
- Some plugins do not work properly on MS
- Adds some complexity on top of everything
- When something breaks it might break everything all at once
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