Modify custom post type rewrite rules in a separate function

Yes, I believe you can. Paste this code into your theme’s functions.php file:

function change_tribe_events_rewrite_rules() {
    global $wp_post_types;
    $rewrite = &$wp_post_types['tribe_events']->rewrite;
    $rewrite['slug'] = 'event/%lugares%';
}
add_action( 'init', 'change_tribe_events_rewrite_rules', 999 );