What PHP Needed to Make One Loop with Multiple Styling?

this is your answer… however like Kaiser said, you should really take some time to read a little…

 <?php 
 $i=0;  
 if ( have_posts() ) while ( have_posts() ) : the_post();
      if($i==0) { ?>

         // YOUR FIRST POST CONTENT

      } else if(($i==1) || ($i==2) || ($i==3)) {

         // POST 2, 3, 4

      } else {

         // everything else

      }
 $i++;
 endwhile;

This is a fast answer and is not the ideal approach, but it will solve your problem…

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