WordPress loop based on url sting

use $_GET['Price'] and $_GET['Region'] to get the price and region values from the url and add them to your query args. It is rather hard without any code to start from, but try something like

$queryPrice = (strpos($_GET['Price'],'-') ? explode('-', $_GET['Price']) : array($_GET['Price'], $_GET['Price']));
$queryRegion = $_GET['Region'];

$args = array(
    // all your args here
    'meta_query' => array(
        'relation' => 'AND',
        array(
            'key' => 'your_acf_price_field',
            'value' => $queryPrice,
            'type' => 'NUMERIC',
            'compare' => 'BETWEEN',
        )
        array(
            'key' => 'your_acf_region_field',
            'value' => $queryRegion,
            'compare' => '=',
        ),  
    )
);

$query = new WP_Query( $args );

Find more info in the acf documentation or on wpse