WP_Query most viewed posts, in multiple Post Types, last 30 days, excluding a specific taxonomy term

You can try:

$the_query = new WP_Query( array(
    'posts_per_page' => '5',
    'v_sortby' => 'views', 
    'post_type' => array( 'post', 'music', 'videos', 'albums' ),
    'tax_query' => array(
        array(
            'taxonomy' => 'content',
            'field' => 'slug',
            'terms' => array( 'indy' ),
            'operator' => 'NOT IN'
        )
    )
));

to exclude the indy term in the content taxonomy.