The performance and load speed may be slowed down because of badly coded frameworks, or even well coded frameworks but way too overloaded. so it really depends on what framework or theme builder you are using and each one to its own case.
As for enabling BuddyPress, first you will need a theme that is made for BuddyPress and as far as i can tell Suffusion is not BuddyPress ready (I could be wrong here). And as for performance problem once again that is theme/theme framework depended.
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