Update
As I deleted the Repo on GitHub, here’s a new answer.
add_filter( 'previous_post_link"https://wordpress.stackexchange.com/questions/13044/,"wpse13044_adjacent_post_link_tooltip', 10, 2 );
add_filter( 'next_post_link"https://wordpress.stackexchange.com/questions/13044/,"wpse13044_adjacent_post_link_tooltip', 10, 2 );
function wpse13044_adjacent_post_link_tooltip( $format, $link )
{
$previous="previous_post_link" === current_filter();
// Get the next/previous post object
$post = get_adjacent_post(
false
,''
,$previous
);
// Copypasta from cores `get_adjacent_post_link()` fn
'' === $title = get_the_title( $post->ID );
AND $title = $previous
? sprint( __( 'Previous Post: %s"https://wordpress.stackexchange.com/questions/13044/,"your_textdomain' ), $title )
: sprint( __( 'Next Post: %s"https://wordpress.stackexchange.com/questions/13044/,"your_textdomain' ), $title );
$format = str_replace(
'rel="'
,sprintf(
'title="%s" rel="'
,$title
)
,$format
);
return "<span class="some classes">{$format}</span>";
}