How to show only specific tag in wordpress loop

Here are two alternative for you based on your actual query. If you’re querying $projects->have_posts() on WP default blog (Post) you can use query like

$projects = new WP_Query( array( 'tag__in' => array( 52, 53 ) ) );

Another is if you’re querying on Custom Post Type you can use following query to get posts or your desire tags.

$array = array (
'post_type' => 'your custom post type',
'posts_per_page' => 10,
// Your other criteria of the query
'tax_query' => array(
    array(
        'taxonomy' => 'name of your tag taxonomy',
        'field' => 'id',
        'terms' => array(52,53)
    )
);

$projects = new WP_Query( $array );

if ( $projects->have_posts() ){
   while ( $projects->have_posts() ) { $projects->the_post(); ?>
         <div <?php post_class(); ?>>
              <a href="https://wordpress.stackexchange.com/questions/349961/<?php the_permalink(); ?>" class="thumb">
                 <?php the_post_thumbnail( $image_size ); ?>
                 <div class="portfolio-hover">
                     <div class="portfolio-description">
                         <h4><?php the_title(); ?></h4>
                         <div><?php the_excerpt(); ?></div>
                     </div>
                 </div>
              </a>
         </div>
      <?php   
   }
}

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